STUDIES ON THE DIFFERENT METABOLIC PATHWAYS OF ANTIPYRINE IN MAN. I: ORAL ADMINISTRATION OF 250, 500 AND 1000 MG TO HEALTHY VOLUNTEERSDANHOF M; BREIMER DD.1979; BRIT. J. CLIN. PHARMACOL.; GBR; DA. 1979; VOL. 8; NO 6; PP. 529-537; BIBL. 26 REF.Article

Electroencephalography parameters as biomarkers: Extrapolation from laboratory animals to humansDANHOF, M.Methods and findings in experimental and clinical pharmacology. 2002, Vol 24, pp 63-64, issn 0379-0355, 2 p., SUPDConference Paper

STUDIES ON THE DIFFERENT METABOLIC PATHWAYS OF ANTIPYRINE IN RATS: INFLUENCE OF PHENOBARBITAL AND 3-METHYLCHOLANTHRENE TREATMENTDANHOF M; KROM DP; BREIMER DD et al.1979; XENOBIOTICA; GBR; DA. 1979; VOL. 9; NO 11; PP. 695-702; BIBL. 31 REF.Article

3-HYDROXYMETHYL ANTIPYRINE EXCRETION IN URINE AFTER AN ORAL DOSE OF ANTIPYRINE. A RECONSIDERATION OF PREVIOUSLY PUBLISHED DATA AND SYNTHESIS OF A PURE REFERENCE SUBSTANCEDANHOF M; TEUNISSEN MWE; BREIMER DD et al.1982; PHARMACOLOGY; ISSN 0031-7012; CHE; DA. 1982; VOL. 24; NO 3; PP. 181-184; BIBL. 9 REF.Article

Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development : The 'wooden shoe' paradigmBREIMER, D. D; DANHOF, M.Clinical pharmacokinetics. 1997, Vol 32, Num 4, pp 259-267, issn 0312-5963Article

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysisMANDEMA, J. W; DANHOF, M.Journal of pharmacokinetics and biopharmaceutics. 1990, Vol 18, Num 5, pp 459-481, issn 0090-466X, 23 p.Article

Kinetics of drug action in disease states. I: Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflexDANHOF, M; LEVY, G.The Journal of pharmacology and experimental therapeutics. 1984, Vol 229, Num 1, pp 44-50, issn 0022-3565Article

Bridging Strategies for Drug Combinations in Pediatric IndicationsCELLA, M; DANHOF, M; PASQUA, O. Della et al.Clinical pharmacology and therapeutics. 2012, Vol 91, Num 4, pp 726-733, issn 0009-9236, 8 p.Article

A system approach to pharmacodynamics. III, An algorithm and computer program, COLAPS, for pharmacodynamic modelingVENG-PEDERSEN, P; MENDAMA, J. W; DANHOF, M et al.Journal of pharmaceutical sciences. 1991, Vol 80, Num 5, pp 488-495, issn 0022-3549, 8 p.Article

Estimation of amobarbital plasma-effect site equilibration kinetics : relevance of polyexponential conductance functionsMANDEMA, J. W; VENG-PEDERSEN, P; DANHOF, M et al.Journal of pharmacokinetics and biopharmaceutics. 1991, Vol 19, Num 6, pp 617-634, issn 0090-466XArticle

Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats : influence of rate and route of administrationMANDEMA, J. W; TUKKER, E; DANHOF, M et al.British journal of pharmacology. 1991, Vol 102, Num 3, pp 663-668, issn 0007-1188, 6 p.Article

INFLUENCE OF THE GENETICALLY CONTROLLED DEFICIENCY IN DEBRISOQUINE HYDROXYLATION ON ANTIPYRINE METABOLITE FORMATIONDANHOF M; IDLE JR; TEUNISSEN MWE et al.1981; PHARMACOLOGY; ISSN 0031-7012; CHE; DA. 1981; VOL. 22; NO 6; PP. 349-358; BIBL. 2 P.Article

Pharmaco-electroencephalography and pharmacokinetic-pharmacodynamic modeling in drug development: Focus on preclinical stepsDANHOF, M; VISSER, S. A. G.Methods and findings in experimental and clinical pharmacology. 2002, Vol 24, pp 127-128, issn 0379-0355, 2 p., SUPDConference Paper

Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy : kindling, cortical stimulation and genetic absence epilepsyCLETON, A; VOSKUYL, R. A; DANHOF, M et al.British journal of pharmacology. 1998, Vol 125, Num 4, pp 615-620, issn 0007-1188Article

In vivo charaterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist : midazolam and flumazenilMANDEMA, J. W; TUKKER, E; DANHOF, M et al.The Journal of pharmacology and experimental therapeutics. 1992, Vol 260, Num 1, pp 36-44, issn 0022-3565Article

A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the ratAARONS, L; MANDEMA, J. W; DANHOF, M et al.Journal of pharmacokinetics and biopharmaceutics. 1991, Vol 19, Num 5, pp 485-496, issn 0090-466XArticle

Determination of the threshold for convulsions by direct cortical stimulationVOSKUYL, R. A; DINGEMANSE, J; DANHOF, M et al.Epilepsy research. 1989, Vol 3, Num 2, pp 120-129, issn 0920-1211Article

Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overviewDINGEMANSE, J; DANHOF, M; BREIMER, D. D et al.Pharmacology & therapeutics (Oxford). 1988, Vol 38, Num 1, pp 1-52, issn 0163-7258Article

Kinetics of drug action in disease states. XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in ratsDANHOF, M; HISAOKA, M; LEVY, G et al.Journal of pharmaceutical sciences. 1985, Vol 74, Num 3, pp 321-324, issn 0022-3549Article

Validation and testing of a new iontophoretic continuous flow through transport cellVAN DER GEEST, R; DANHOF, M; BODDE, H. E et al.Journal of controlled release. 1998, Vol 51, Num 1, pp 85-91, issn 0168-3659Article

Iontophoretic delivery of apomorphine I : In vitro optimization and validationVAN DER GEEST, R; DANHOF, M; BODDE, H. E et al.Pharmaceutical research. 1997, Vol 14, Num 12, pp 1798-1803, issn 0724-8741Article

Properties of the convulsice threshold determined by direct cortical stimulation in ratsVOSKUYL, R. A; HOOGERKAMP, A; DANHOF, M et al.Epilepsy research. 1992, Vol 12, Num 2, pp 111-120, issn 0920-1211Conference Paper

Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationshipMANDEMA, J. W; KUCK, M. T; DANHOF, M et al.British journal of pharmacology. 1992, Vol 105, Num 1, pp 164-170, issn 0007-1188Article

Pharmacodynamic characterization of the electroencephalographic effects of thiopental in ratsEBLING, W. F; DANHOF, M; STANSKI, D. R et al.Journal of pharmacokinetics and biopharmaceutics. 1991, Vol 19, Num 2, pp 123-143, issn 0090-466X, 21 p.Article

Characterization of endogenous viral loci in five lines of White Leghorn chickens = Caractérisation des loci de virus endogènes dans cinq lignées de poulets White LeghornHUMPHRIES, E. H; DANHOF, M. L; HLOZANEK, I et al.Virology (New York, NY). 1984, Vol 135, Num 1, pp 125-138, issn 0042-6822Article